By Allium Research
Onchain Execution: How Institutions Are Trading in DeFi Markets
A joint perspective from Uniswap Labs and Allium on the infrastructure enabling institutional DeFi adoption
The institutional conversation around trading onchain has shifted from "if" to "how" over the past 18-24 months. What was once viewed as experimental infrastructure for retail traders now represents a strategic venue for institutional execution—one that offers transparent liquidity, atomic settlement, and competitive pricing.
The shift to onchain trading has been enabled by fundamental improvements across custody, compliance, and execution infrastructure. Solutions like Fireblocks and Anchorage Digital now provide institutional-grade custody that integrates natively with DeFi protocols. Trading platforms have evolved to offer unified, API-driven access that fits existing institutional workflows. The result: institutions can now execute onchain without disrupting operational processes or compromising on the standards they expect from traditional venues.

Other reports

Tokenized Equities Onchain: $3.3B and Growing
May 2026
Tokenized stocks, indices, commodities, pre-IPO & FX traded as perps on HL via HIP-3 builder books.

Hyperliquid non-crypto perps
May 2026
Tokenized stocks, indices, commodities, pre-IPO & FX traded as perps on HL via HIP-3 builder books.

Ondo Finance (ONDO)
May 2026
Ondo is the only large-scale RWA-platform issuer with a publicly-tradeable token. The underlying business is real and category-leading: $3.43B platform AUM across USDY ($2.10B, 8 chains), OUSG ($285M), and Tokenized Stocks ($1.04B, 268 symbols), with +$1.4B of net USDY inflows in 2026 H1.
